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| Etape Tur | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | 11 | 12 | 13 | 14 | 15 |
| Etape Retur | 16 | 17 | 18 | 19 | 20 | 21 | 22 | 23 | 24 | 25 | 26 | 27 | 28 | 29 | 30 |
  | 27 August 2021, 18:00 |  | FC Voluntari | 2-1 | Chindia Targoviste |  |  |
| | 27 August 2021, 21:00 |  | FC U Craiova 1948 | 1-1 | Farul Constanta |  | |
| | 28 August 2021, 18:00 |  | Dinamo Bucuresti | 0-2 | FC Arges |  | |
| | 28 August 2021, 21:00 |  | Rapid Bucuresti | 1-2 | CS Universitatea Craiova |  | |
| | 29 August 2021, 18:15 |  | Sepsi OSK | 1-1 | FC Botosani |  | |
| | 29 August 2021, 21:00 |  | CFR Cluj | 4-1 | FCSB |  | |
| | 30 August 2021, 18:00 |  | Academica Clinceni | 1-1 | CS Mioveni |  | |
| | 30 August 2021, 21:00 |  | Gaz Metan Medias | 0-1 | UTA Arad |  | |
| Pozitia | Echipa | Meciuri | Victorii | Egaluri | Infrangeri | Golaveraj | Puncte | Adevar |
| 1 | CFR Cluj | 7 | 7 | 0 | 0 | 13-4 (9) | 21 (11) | (+9) |
| 2 | Rapid Bucuresti | 7 | 5 | 1 | 1 | 8-2 (6) | 16 (8) | (+4) |
| 3 | UTA Arad | 7 | 4 | 2 | 1 | 7-3 (4) | 14 (7) | (+2) |
| 4 | FC Botosani | 7 | 4 | 2 | 1 | 7-5 (2) | 14 (7) | (+5) |
| 5 | Farul Constanta | 7 | 3 | 3 | 1 | 7-2 (5) | 12 (6) | (+3) |
| 6 | CS Universitatea Craiova | 7 | 4 | 0 | 3 | 9-8 (1) | 12 (6) | (0) |
| Playout | ||||||||
| 7 | CS Mioveni | 7 | 3 | 1 | 3 | 5-6 (-1) | 10 (5) | (+1) |
| 8 | FCSB | 7 | 2 | 3 | 2 | 9-9 (0) | 9 (5) | (0) |
| 9 | FC Voluntari | 7 | 3 | 0 | 4 | 7-11 (-4) | 9 (5) | (-3) |
| 10 | FC U Craiova 1948 | 7 | 2 | 2 | 3 | 7-8 (-1) | 8 (4) | (-1) |
| 11 | FC Arges | 7 | 2 | 1 | 4 | 6-6 (0) | 7 (4) | (-2) |
| 12 | Sepsi OSK | 7 | 1 | 3 | 3 | 6-8 (-2) | 6 (3) | (-6) |
| 13 | Chindia Targoviste | 7 | 1 | 3 | 3 | 5-7 (-2) | 6 (3) | (-3) |
| 14 | Dinamo Bucuresti | 7 | 2 | 0 | 5 | 6-11 (-5) | 6 (3) | (-6) |
| 15 | Gaz Metan Medias | 7 | 1 | 1 | 5 | 4-9 (-5) | 4 (2) | (-8) |
| 16 | Academica Clinceni | 7 | 0 | 2 | 5 | 6-13 (-7) | 2 (1) | (-7) |
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